Review



src family kinase sfk py416  (Cell Signaling Technology Inc)


Bioz Verified Symbol Cell Signaling Technology Inc is a verified supplier
Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 96

    Structured Review

    Cell Signaling Technology Inc src family kinase sfk py416
    Src Family Kinase Sfk Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 2354 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pm20583816__cb100099h_si_001-12-10-15
    Average 96 stars, based on 2354 article reviews
    src family kinase sfk py416 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    Related Articles

    Blocking Assay:

    Article Title: Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia
    Article Snippet: .. Primary antibodies against Lyn kinase (sc-7274; Santa Cruz S2 Biotechnology), Src-family kinase (SFK) pY416 (#2101; Cell Signaling Technology, Danvers, MA), and SFK pY527 (#2105; Cell Signaling) were diluted at 1:1000 in the blocking solution or 1% bovine serum albumin/TBST and applied to a membrane overnight at 4 °C or 1 hr at room temperature. ß-actin was also measured to serve as a loading control (sc-47778; Santa Cruz Biotechnology). ..

    Membrane:

    Article Title: Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia
    Article Snippet: .. Primary antibodies against Lyn kinase (sc-7274; Santa Cruz S2 Biotechnology), Src-family kinase (SFK) pY416 (#2101; Cell Signaling Technology, Danvers, MA), and SFK pY527 (#2105; Cell Signaling) were diluted at 1:1000 in the blocking solution or 1% bovine serum albumin/TBST and applied to a membrane overnight at 4 °C or 1 hr at room temperature. ß-actin was also measured to serve as a loading control (sc-47778; Santa Cruz Biotechnology). ..

    Control:

    Article Title: Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia
    Article Snippet: .. Primary antibodies against Lyn kinase (sc-7274; Santa Cruz S2 Biotechnology), Src-family kinase (SFK) pY416 (#2101; Cell Signaling Technology, Danvers, MA), and SFK pY527 (#2105; Cell Signaling) were diluted at 1:1000 in the blocking solution or 1% bovine serum albumin/TBST and applied to a membrane overnight at 4 °C or 1 hr at room temperature. ß-actin was also measured to serve as a loading control (sc-47778; Santa Cruz Biotechnology). ..

    Phospho-proteomics:

    Article Title: Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase-Deficient Renal Cell Carcinoma
    Article Snippet: .. The catalog number and the phosphorylation site recognized are: pEGFR (3777, pY1068, Cell Signaling, Danvers, MA, USA, RRID:AB_2096270); EGFR (4267, Cell Signaling, RRID:AB_2895042); pSRC (6943, pY416, Cell Signaling, RRID: AB_10013641); SRC (2109, Cell Signaling, RRID:AB_2106059); Signaling); pAKT (4058, pS473, Cell Signaling, RRID:AB_331168); and AKT (4691, Cell Signaling, RRID:AB_915783). ..

    Immunofluorescence:

    Article Title: The Aurora B inhibitor ZM-447439 induces caspase-independent necrosis-like death in v-Src oncogene-expressing cells via accumulation of extra-lysosomal cathepsin B.
    Article Snippet: Src signaling is aberrantly activated in various cancers, and therapeutic strategies targeting Src-dependent cancers have been developed.. We previously reported that cells expressing the oncogenic mutant v-Src are resistant to microtubule-targeting agents (MTAs), yet paradoxically exhibiting sensitivity to the Aurora B inhibitor ZM-447439; however, the mechanism underlying this cytotoxicity remains unclear.. In this study, we demonstrate that the Aurora B inhibitor ZM-447439 potentiates cell death in v-Src-expressing HeLa S3 and HCT116 cells, accompanied by the accumulation of tetraploid and polyploid cells.

    Western Blot:

    Article Title: The Aurora B inhibitor ZM-447439 induces caspase-independent necrosis-like death in v-Src oncogene-expressing cells via accumulation of extra-lysosomal cathepsin B.
    Article Snippet: Src signaling is aberrantly activated in various cancers, and therapeutic strategies targeting Src-dependent cancers have been developed.. We previously reported that cells expressing the oncogenic mutant v-Src are resistant to microtubule-targeting agents (MTAs), yet paradoxically exhibiting sensitivity to the Aurora B inhibitor ZM-447439; however, the mechanism underlying this cytotoxicity remains unclear.. In this study, we demonstrate that the Aurora B inhibitor ZM-447439 potentiates cell death in v-Src-expressing HeLa S3 and HCT116 cells, accompanied by the accumulation of tetraploid and polyploid cells.

    Flow Cytometry:

    Article Title: The Aurora B inhibitor ZM-447439 induces caspase-independent necrosis-like death in v-Src oncogene-expressing cells via accumulation of extra-lysosomal cathepsin B.
    Article Snippet: Src signaling is aberrantly activated in various cancers, and therapeutic strategies targeting Src-dependent cancers have been developed.. We previously reported that cells expressing the oncogenic mutant v-Src are resistant to microtubule-targeting agents (MTAs), yet paradoxically exhibiting sensitivity to the Aurora B inhibitor ZM-447439; however, the mechanism underlying this cytotoxicity remains unclear.. In this study, we demonstrate that the Aurora B inhibitor ZM-447439 potentiates cell death in v-Src-expressing HeLa S3 and HCT116 cells, accompanied by the accumulation of tetraploid and polyploid cells.

    other:

    Article Title: Reciprocal regulation of Solo and Src orchestrates Src trafficking to promote mesenchymal cell migration
    Article Snippet: Rabbit anti-pY416 Src , Cell Signaling Technology , Cat# 6943; RRID: AB_10013641.



    Similar Products

    96
    Cell Signaling Technology Inc src family kinase sfk py416
    Src Family Kinase Sfk Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pm20583816__cb100099h_si_001-12-10-15
    Average 96 stars, based on 1 article reviews
    src family kinase sfk py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc c src py416
    KEY RESOURCES TABLE
    C Src Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pmc11869325-11-0-3
    Average 96 stars, based on 1 article reviews
    c src py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc src py416
    KEY RESOURCES TABLE
    Src Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pm39251588-462-23-24
    Average 96 stars, based on 1 article reviews
    src py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    90
    Cell Signaling Technology Inc phospho-src family (py416) antibody
    KEY RESOURCES TABLE
    Phospho Src Family (Py416) Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/anti+phospho+src/pm38339971-160-1-8
    Average 90 stars, based on 1 article reviews
    phospho-src family (py416) antibody - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc psrc family py416
    KEY RESOURCES TABLE
    Psrc Family Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pm37577760-545-31-34
    Average 96 stars, based on 1 article reviews
    psrc family py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc anti phospho src py416
    KEY RESOURCES TABLE
    Anti Phospho Src Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/10__1523_slash_jneurosci__1401___23__2023-147-34-38
    Average 96 stars, based on 1 article reviews
    anti phospho src py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc py416 cell signaling
    KEY RESOURCES TABLE
    Py416 Cell Signaling, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pmc10474047__41420_2023_1615_MOESM5_ESM-2-81-82
    Average 96 stars, based on 1 article reviews
    py416 cell signaling - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    Cell Signaling Technology Inc anti phospho src family py416
    KEY RESOURCES TABLE
    Anti Phospho Src Family Py416, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-src+family+(py416)+antibody/Phospho-Src+Family+(Tyr416)+Antibody/pmc10445741-158-0-73
    Average 96 stars, based on 1 article reviews
    anti phospho src family py416 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    Image Search Results


    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation

    doi: 10.1016/j.celrep.2023.113361

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: c-SRC (pY416) , Cell Signaling Technology , Cat# 2101; RRID:AB_331697.

    Techniques: Virus, Recombinant, Biotin Switch Assay, Mutagenesis, Control, Sequencing, Software